For users running games off a hard drive or SMB, using a GameShark ISO is less common today because OPL has a built-in cheat engine (Cheat Device). However, some still prefer the V7 interface. You would boot the ISO just like any other game, select cheats, and then use the "Eject/Load" method if your hardware supports it. The Importance of Master Codes
Cheats Not Loading: Ensure you haven't selected too many codes at once; the PS2's memory can only handle so many simultaneous "hooks." Gameshark Ps2 Iso V7
Black Screen on Boot: This often happens if the ISO region (NTSC/PAL) doesn't match your console or BIOS settings. For users running games off a hard drive
Load the ISO: Open PCSX2 and select the Gameshark V7 ISO as your "Disc." The Importance of Master Codes Cheats Not Loading:
Using a cheat ISO is slightly different depending on whether you are using hardware or software. On PCSX2 (PC Emulator)