If you are determined to play Resident Evil 4 on a handheld today, you have much better official options than a buggy fan ISO:
The search for a file is one of the most persistent quests in the retro gaming and emulation community. While many websites claim to offer a direct download of Leon S. Kennedy’s Spanish adventure for the PlayStation Portable (PSP), the reality behind these files is a mix of fan-made "demakes," clever mods, and a healthy dose of internet myth. The Hard Truth: Did Capcom Ever Release RE4 for PSP? Resident Evil 4 Psp Iso Cso.zip
: Some "ISO" files are actually heavily modded versions of Resident Evil 2 or 3 (PS1 classics) that have been reskinned to look like Resident Evil 4 . Since the PSP can play PS1 EBOOTs natively, these mods are a common way for fans to get a "portable" fix. If you are determined to play Resident Evil
If you find a .zip or .cso file labeled "Resident Evil 4 PSP," it usually falls into one of three categories: The Hard Truth: Did Capcom Ever Release RE4 for PSP
The short answer is . Capcom never officially developed or released Resident Evil 4 for the PSP.