Simran's entry into the film industry was facilitated by her father, a film producer. She made her acting debut in 1995 with the Tamil film "Varmuki," but it was her breakthrough role in the 1997 film "Gnanapazham" that garnered her recognition. Her early success paved the way for a thriving career, with Simran going on to appear in a wide range of films across various genres.

In addition to her work in Tamil cinema, Simran has appeared in films in other languages, including Telugu, Malayalam, and Kannada. Her performances in these films have been well-received, further solidifying her reputation as a talented and adaptable actress.

Simran is also known for her philanthropic efforts, particularly in the area of education and healthcare. She has been involved with several charitable organizations and has participated in various fundraising events to support these causes.